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Crescent City Rhapsody by Kathleen Ann Goonan


Basically, this is the story of the transformation of the world by nanotech on the scale of taking entire cities and translating them into versions that function as a coordinated entity.

The central character, Marie Laveau, plays an odd role.  Sort of like a Robin Hood - a criminal acting to change society for the benefit of most of the people.  Unlike Robin Hood, it is not merely circumstances that have temporarily led her to use illegal means to regain her rightful place - she starts out as an underworld figure.  She is not motivated by being unfairly outcast and she's not trying to bring things back to the good old days.  She's not the Godfather, and she's more interested in technology.  Still, it's not the most likely person for a champion of the people.

Perhaps, it is partly that early on she is assassinated by rivals.  She has made arrangements so that in such a case her body is rushed to a facility and an experimental bio/nano treatment is used to restore her more or less to her previous self.  But the treatment has its drawbacks.

One way or the other, over the course of years she leads efforts to transform New Orleans and the world.

The world is also being assaulted by periodic space radiation that damages microchips, seriously affecting related technologies.  (In one of the less plausible elements, this somehow leads to children being born who sense electromagnetism more than others.)  Eventually, it is discovered that radiation includes a communication from extraterrestrials that may be useful to Earth.

Another important character, Zeb, is a genius scientist with a psychiatric condition.  He ends up off his medication, going through periods of mental illness and periods during which he can develop his understanding of the alien signals.  The government wants to control or stop his research, so he lives in more-or-less homeless anonymity.

In another subplot, a Japanese firm has created nano "universal assemblers", which could pose a grave threat if used by the wrong people or in the wrong way.

And elsewhere, an army of abused women is led by a dangerous woman planning a new form of revenge.

The world is in turmoil.  Nano attacks are escalating to the point of swarms of nano "insects" taking over cities...

The book is a prequel to Queen City Jazz, and is part of a 4-book nanotech series.